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C., making it a principal city in the Washington-Baltimore combined statistical area (CSA), the fourth largest CSA in the nation with a calculated 2016 population of 9,665,892.After a decline in major manufacturing, industrialization, and rail transportation, Baltimore shifted to a service-oriented economy, with Johns Hopkins Hospital (founded 1889) and Johns Hopkins University (founded 1876), now the city's top two employers.Soon after the city created the world's first dental college, the Baltimore College of Dental Surgery, in 1840, and shared in the world's first telegraph line, between Baltimore and Washington DC in 1844.Maryland, a slave state with abundant popular support for secession in some areas, remained part of the Union during the American Civil War, due in part to the Union's strategic occupation of the city in 1861.Following the death of Freddie Gray in April 2015, the city experienced major protests and international media attention, as well as a clash between local youth and police which resulted in a state of emergency declaration and curfew.
These industries benefited from war but successfully shifted into infrastructure development during peacetime.
Strikers clashed with the National Guard, leaving 10 dead and 25 wounded.
On February 7, 1904, the Great Baltimore Fire destroyed over 1,500 buildings in 30 hours, leaving more than 70 blocks of the downtown area burned to the ground.
Damages were estimated at 0 million—in 1904 dollars.
The Baltimore riot of 1968, coinciding with riots in other cities, followed the assassination of Martin Luther King, Jr. Public order was not restored until April 12, 1968.